Author's response to reviews Title:Hyperammonia Induces Specific Liver Injury through an Intrinsic Ca2+-independent Apoptosis Pathway Authors:

Hyperammonia induces specific liver injury through an intrinsic Ca2+-independent apoptosis pathway

BACKGROUND Numerous pathological processes that affect liver function in patients with liver failure have been identified. Among them, hyperammonia is one of the most common phenomena.The purpose of this study was to determine whether hyperammonia could induced specific liver injury. METHODS Hyperammonemic cells were established using NH4Cl. The cells were assessed by MTT, ELISA, and flow cyt...

Author's response to reviews Title: Poly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway Authors:

Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat

Objective(s): Iranian crack (IC) is a heroin-based substance manifesting various pathologic side effects. Herein, we aimed to investigate the mechanism of IC-induced liver injuries in Wistar rats. Materials and Methods: Twenty male Wistar rats were randomly divided into two groups: control, and IC (0.9 mg/kg/day/IP, for 30 days). Mitochondrial reactive oxygen species (ROS) production was measur...

Author's response to reviews Title: Pinocembrin protects against beta-amyloid-induced toxicity in neurons through inhibiting RAGE-independent signaling pathways and regulating mitochondrion-mediated apoptosis Authors:

Author's response to reviews Title: Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma Authors: